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Many people who wear contact lenses complain of dry eyes by the end of the day. If you have tried re-wetting drops and they didn't help, you might need to ask your doctor about changing lenses. There are three contact lenses on the market that are known to be particularly good for this problem - the Acuvue Advanced, the Proclear Biocompatibles, and the O2-Optix Contact Lenses. Ask your doctor to let you try one of these - you might be very happy with the results.