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Giant papillary conjunctivitis is an inflammation of the inner surface of the eyelids and it can be caused by wearing contact lenses. The inflammation is an immune response, which often results when the body perceives the contact lens to be a foreign body that must be destroyed. In many cases, switching to a contact lens made of a different material can alleviate the inflammation. Other treatments include discontinued or limited use of contact lenses as well as the use of steroids to mitigate the inflammation. Talk to your doctor if you're feeling discomfort or noticing signs of an infection.